Mycobacterium tuberculosisESAT-6 antigen immunogenicity in Owl Monkeys
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چکیده
منابع مشابه
Mycobacterium tuberculosis ESAT-6 antigen immunogenicity in Owl Monkeys
Several ESAT-6-based vaccines have been widely studied in different animal models, presenting potent ability to induce both cellular and humoral responses. As ESAT-6 is a well-characterized mycobacterial antigen, its capacity to induce immune responses in a nonhuman primate model has been evaluated. The immunization of recombinant ESAT-6 (rESAT-6) in Aotus nancymaae monkeys has elicited a stron...
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We constructed two recombinant Mycobacterium bovis BCG (rBCG) strains expressing ESAT-6 of Mycobacterium tuberculosis, named rBCG-1 and rBCG-2. rBCG-1 contained the ESAT-6 gene linked to BCG hsp60 and expressed a fusion protein, while rBCG-2, with a secretory sequence, could secret ESAT-6 into the culture medium. There was no evidence for increased virulence of the two rBCG strains when we made...
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ژورنال
عنوان ژورنال: Nova
سال: 2006
ISSN: 2462-9448,1794-2470
DOI: 10.22490/24629448.344